What is DHM? The Hangover Science Behind Our Formula
Dihydromyricetin (DHM) is a flavonoid extracted from the Japanese raisin tree. Here's what the research says about how it works — and why it's the cornerstone of PREGAME.
The Plant Behind the Science
Dihydromyricetin (DHM) — also known as ampelopsin — is a flavonoid found in the Japanese raisin tree (Hovenia dulcis). For centuries, East Asian cultures have used extracts of this plant as a traditional hangover remedy. Western science has spent the last decade figuring out why it works.
How Alcohol Affects Your Brain
Alcohol binds to GABA-A receptors in your brain, enhancing inhibitory signalling. That's the relaxation effect you feel after a drink. But as alcohol is metabolised and clears your system overnight, those same receptors 'rebound' — going hyperactive in the opposite direction. The result: the anxiety, poor sleep quality, and rough mornings that define a hangover.
What DHM Does
Multiple peer-reviewed studies (UCLA, 2012 onwards) show DHM accelerates the liver's clearance of acetaldehyde — the toxic metabolite produced when your body breaks down alcohol. Acetaldehyde is responsible for the headache, nausea, and fatigue that follow a heavy night. DHM also appears to moderate GABA-A receptor rebound, supporting more restful sleep even after drinking.
The PREGAME Dose
We use a clinically-referenced dose of DHM in every 10ml shot — combined with NAC, B-vitamins, and electrolytes for a full-spectrum approach. Our formula is transparent: every milligram disclosed on the label. No proprietary blends, no hidden fillers.
The science is promising. The ingredient is real. That's why DHM anchors every PREGAME shot.